Fitness effects associated with the major flowering time gene FRIGIDA in Arabidopsis thaliana in the field

被引:133
作者
Korves, Tonia M.
Schmid, Karl J.
Caicedo, Ana L.
Mays, Charlotte
Stinchcombe, John R.
Purugganan, Michael D.
Schmitt, Johanna
机构
[1] Max Planck Inst Chem Ecol, Dept Genet & Evolut, D-07745 Jena, Germany
[2] Brown Univ, Dept Ecol & Evolutionary Biol, Providence, RI 02912 USA
[3] N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA
[4] Univ Toronto, Dept Bot, Toronto, ON M5S 3B2, Canada
关键词
epistasis; FLOWERING LOCUS C (FLC); population structure; vernalization; candidate gene association; heterogeneous selection;
D O I
10.1086/513111
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
To date, the effect of natural selection on candidate genes underlying complex traits has rarely been studied experimentally, especially under ecologically realistic conditions. Here we report that the effect of selection on the flowering time gene FRIGIDA (FRI) reverses depending on the season of germination and allelic variation at the interacting gene FLOWERING LOCUS C (FLC). In field studies of 136 European accessions of Arabidopsis thaliana, accessions with putatively functional FRI alleles had higher winter survival in one FLC background in a fall-germinating cohort, but accessions with deletion null FRI alleles had greater seed production in the other FLC background in a spring-germinating cohort. Consistent with FRI's role in flowering, selection analyses suggest that the difference in winter survival can be attributed to time to bolting. However, in the spring cohort, the fitness difference was associated with rosette size. Our analyses also reveal that controlling for population structure with estimates of inferred ancestry and a geographical restriction was essential for detecting fitness associations. Overall, our results suggest that the combined effects of seasonally varying selection and epistasis could explain the maintenance of variation at FRI and, more generally, may be important in the evolution of genes underlying complex traits.
引用
收藏
页码:E141 / E157
页数:17
相关论文
共 77 条
[1]  
ARANZANA MJ, 2006, PLOS GENET, V1, pE60, DOI DOI 10.1371/JOURNAL.PGEN.0010060
[2]   Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range [J].
Bakker, EG ;
Stahl, EA ;
Toomajian, C ;
Nordborg, M ;
Kreitman, M ;
Bergelson, J .
MOLECULAR ECOLOGY, 2006, 15 (05) :1405-1418
[3]   Multiple pathways in the decision to flower: Enabling, promoting, and resetting [J].
Boss, PK ;
Bastow, RM ;
Mylne, JS ;
Dean, C .
PLANT CELL, 2004, 16 (SUPPL.) :S18-S31
[4]   Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait [J].
Caicedo, AL ;
Stinchcombe, JR ;
Olsen, KM ;
Schmitt, J ;
Purugganan, MD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15670-15675
[5]   Demonstrating stratification in a European American population [J].
Campbell, CD ;
Ogburn, EL ;
Lunetta, KL ;
Lyon, HN ;
Freedman, ML ;
Groop, LC ;
Altshuler, D ;
Ardlie, KG ;
Hirschhorn, JN .
NATURE GENETICS, 2005, 37 (08) :868-872
[6]   Population stratification and spurious allelic association [J].
Cardon, LR ;
Palmer, LJ .
LANCET, 2003, 361 (9357) :598-604
[7]  
Donohue K, 2005, EVOLUTION, V59, P758, DOI 10.1111/j.0014-3820.2005.tb01751.x
[8]  
Donohue K, 2002, ECOLOGY, V83, P1006, DOI 10.1890/0012-9658(2002)083[1006:GTINSO]2.0.CO
[9]  
2
[10]   Analysis of selection on enzyme polymorphisms [J].
Eanes, WF .
ANNUAL REVIEW OF ECOLOGY AND SYSTEMATICS, 1999, 30 :301-326