Lithium N-trityl-N-(R)-1-phenethylamide, a readily available and useful base for the enantioselective formation of chiral enolates from achiral ketones
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Busch-Petersen, J
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Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USAHarvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
Busch-Petersen, J
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Corey, EJ
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Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USAHarvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
Corey, EJ
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[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
Lithium N-trityl-N-(R)-1-phenylethylamide (6) is a readily available and useful reagent for the enantioselective (20:1) conversion of 4-t-butylcyclohexanone to the corresponding (S)-enolate. This reaction provides access to numerous useful chiral compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.