Lithium N-trityl-N-(R)-1-phenethylamide, a readily available and useful base for the enantioselective formation of chiral enolates from achiral ketones

被引:30
作者
Busch-Petersen, J [1 ]
Corey, EJ [1 ]
机构
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1016/S0040-4039(00)01185-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Lithium N-trityl-N-(R)-1-phenylethylamide (6) is a readily available and useful reagent for the enantioselective (20:1) conversion of 4-t-butylcyclohexanone to the corresponding (S)-enolate. This reaction provides access to numerous useful chiral compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:6941 / 6944
页数:4
相关论文
共 16 条