Novel class of tertiary phosphine ligands based on a phospha-adamantane framework and use in the Suzuki cross-coupling reactions of aryl halides under mild conditions
被引:84
作者:
Adjabeng, G
论文数: 0引用数: 0
h-index: 0
机构:Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
Adjabeng, G
Brenstrum, T
论文数: 0引用数: 0
h-index: 0
机构:Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
Brenstrum, T
Wilson, J
论文数: 0引用数: 0
h-index: 0
机构:Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
Wilson, J
Frampton, C
论文数: 0引用数: 0
h-index: 0
机构:Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
Frampton, C
Robertson, A
论文数: 0引用数: 0
h-index: 0
机构:Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
Robertson, A
Hillhouse, J
论文数: 0引用数: 0
h-index: 0
机构:Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
Hillhouse, J
McNulty, J
论文数: 0引用数: 0
h-index: 0
机构:Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
McNulty, J
Capretta, A
论文数: 0引用数: 0
h-index: 0
机构:
Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, CanadaBrock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
Capretta, A
[1
]
机构:
[1] Brock Univ, Dept Chem, Inst Mol Catalysis, St Catharines, ON L2S 3A1, Canada
[2] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
[3] Cytec Canada Inc, Niagara Falls, ON L2E 6T4, Canada
A new class of sterically hindered phosphines based on a phospha-adamantane framework is described. Arylation or alkylation of the 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phospha-adamantane system allows for the preparation of tertiary phosphines suitable for use in palladium-catalyzed cross-coupling reactions. For example, use of a catalytic system incorporating Pd-2(dba)(3) and 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phosphaadamantane is shown to promote the Suzuki cross-coupling of aryl iodides, bromides, and activated chlorides with a variety of aryl boronic acids at room temperature in a few hours with high yields.