Apototic signaling cascades

被引：126

作者：

Ashe, PC ^{[1
]}

Berry, MD ^{[1
]}

机构：

[1] Alviva Biopharmaceut Inc, Saskatoon, SK S7N 3R2, Canada

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2003年 / 27卷 / 02期

关键词：

apoptosis; bcl-2; proteins; caspases; death receptor; mitochondria; signal transduction;

D O I：

10.1016/S0278-5846(03)00016-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Apoptosis is a form of programmed cell death that results in the orderly and efficient removal of damaged or unnecessary cells, such as those resulting from DNA damage or during development. There are many factors that contribute to this process, each demonstrating specificity of function, regulation, and pathway involvement. The aim of this brief overview is to provide an introduction to a number of these factors as well as the various apoptotic pathways that have been identified. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：199 / 214

页数：16

共 197 条

[11] The regulation of anoikis: MEKK-1 activation requires cleavage by caspases [J].

Cardone, MH ;

Salvesen, GS ;

Widmann, C ;

Johnson, G ;

Frisch, SM .

CELL, 1997, 90 (02) :315-323

[12] A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling [J].

Chan, FKM ;

Chun, HJ ;

Zheng, LX ;

Siegel, RM ;

Bui, KL ;

Lenardo, MJ .

SCIENCE, 2000, 288 (5475) :2351-2354

[13]

Chan SL, 1999, J NEUROSCI RES, V58, P167, DOI 10.1002/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.3.CO

[14]

2-B

[15] Proteases for cell suicide: Functions and regulation of caspases [J].

Chang, HY ;

Yang, XL .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (04) :821-+

[16] Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx [J].

Chang, HY ;

Nishitoh, H ;

Yang, XL ;

Ichijo, H ;

Baltimore, D .

SCIENCE, 1998, 281 (5384) :1860-1863

[17] Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway [J].

Chaudhary, PM ;

Eby, M ;

Jasmin, A ;

Bookwalter, A ;

Murray, J ;

Hood, L .

IMMUNITY, 1997, 7 (06) :821-830

[18] TNF-R1 signaling: A beautiful pathway [J].

Chen, GQ ;

Goeddel, DV .

SCIENCE, 2002, 296 (5573) :1634-1635

[19] Conversion of Bcl-2 to a Bax-like death effector by caspases [J].

Cheng, EHY ;

Kirsch, DG ;

Clem, RJ ;

Ravi, R ;

Kastan, MB ;

Bedi, A ;

Ueno, K ;

Hardwick, JM .

SCIENCE, 1997, 278 (5345) :1966-1968

[20] Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95 [J].

Chinnaiyan, AM ;

ORourke, K ;

Yu, GL ;

Lyons, RH ;

Garg, M ;

Duan, DR ;

Xing, L ;

Gentz, R ;

Ni, J ;

Dixit, VM .

SCIENCE, 1996, 274 (5289) :990-992

← 1 2 3 4 5 6 7 8 9 10 →