Role of tight junctions in cell proliferation and cancer

被引：119

作者：

Gonzalez-Mariscal, Lorenza ^{[1
]}

Lechuga, Susana ^{[1
]}

Garay, Erika ^{[1
]}

机构：

[1] CINVESTAV, Ctr Res & Adv Studies, Dept Physiol Biophys & Neurosci, Mexico City 07360, DF, Mexico

来源：

PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY | 2007年 / 42卷 / 01期

关键词：

cancer; tight junctions; claudins; occludin; ZO-1; PDZ; oncoproteins;

D O I：

10.1016/j.proghi.2007.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The acquisition of a cancerous phenotype by epithelial cells involves the disruption of intercellular adhesions. The reorganization of the E-cadherin/beta-catenin complex in adherens junctions during cell transformation is widely recognized. Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer. (c) 2007 Elsevier GmbH. All rights reserved.

引用

页码：1 / 57

页数：57

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