Electrical stimulation of the lower midbrain around retrorubral field decreases temperatures of brown fat and rectum in anesthetized Wistar rats

被引：10

作者：

Hashimoto, M

Arita, J

Shibata, M

机构：

[1] Yamanshim Med Univ, Dept Physiol, Yamanashi 4093898, Japan

[2] Yamanashi Inst Environm Sci, Dept Biometeorol, Yamanashi, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 246卷 / 03期

关键词：

brown adipose tissue; electrical stimulation; lower midbrain; body temperature regulation; tonic inhibition; metabolic heat production; procaine;

D O I：

10.1016/S0304-3940(98)00206-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

To investigate a neuronal mechanism controlling heat production of brown adipose tissue (BAT), ventral regions of the lower midbrain was stimulated by rectangular electric current (0.1 ms, 1 mA, 5-50 Hz) while recording temperatures of the interscapular BAT (IBAT), rectum and arterial blood pressure in urethane-anesthetized Wistar rats at room temperature of 24-26 degrees C. Unilateral stimulation (10 Hz) for 5 min to the midbrain around the retrorubral field decreased temperatures of IBAT (0.33 +/- 0.03 degrees C, n = 33) and rectum (0.10 +/- 0.01 degrees C). The response was reversed when procaine (10%, 800 nl) was injected into the same locus. The results support the hypothesis that a tonic inhibitory mechanism for metabolic heat production locates around the retrorubral field. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：129 / 132

页数：4

共 17 条

[1]

BRAIN-STEM TONIC INHIBITION OF THERMOREGULATION IN THE RAT [J].