Eicosanoid biosynthesis:: Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase

被引：11

作者：

Falck, JR

Belosludtsev, YY

Reddy, KK

Reddy, KM

Shortt, MF

Chauhan, K

Capdevila, JH ^{[1
]}

Wei, SZ

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75235 USA

[3] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 23期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(97)10144-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Biphenyl 4 and vinyldibromide 8 were prepared on a multigram scale and shown to be comparatively specific arachidonic acid epoxygenase and omega-hydroxylase inhibitors, respectively, in rat kidney microsomal fractions. (C) 1997 Elsevier Science Ltd.

引用

页码：3053 / 3056

页数：4

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