The platelet indices in patients with rheumatoid arthritis: Mean platelet volume reflects disease activity

被引:210
作者
Yazici, S. [1 ]
Yazici, M. [1 ]
Erer, B. [1 ]
Erer, B. [1 ]
Calik, Y. [1 ]
Ozhan, H. [1 ]
Ataoglu, S. [1 ]
机构
[1] Umraniye Training & Res Hosp, Istanbul, Turkey
关键词
Mean platelet volume; rheumatoid arthritis; METHOTREXATE;
D O I
10.3109/09537100903474373
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The present study was designed to investigate the interaction between platelet indices, inflammatory markers and disease activity in rheumatoid arthritis (RA) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 97 patients with RA (19 men, 78 women: mean age 51 years) and 33 age and sex-matched healthy subjects as a control group. All RA patients were administered conventional therapy. After 3 months of therapy, 35 subjects who had high disease activity score (DAS28 > 5.1) were grouped as non-responders and were administered infliximab as a TNF-alpha blocker at the standard intravenous dose. Responders to the conventional therapy and non-responders were also compared. At baseline white blood cell (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), platelet count and mean platelet volume (MPV) were significantly higher in patients with RA. Mean platelet volume was positively correlated with DAS28 score (r = 0.27; p = 0.007). These markers of inflammation and platelet indices were substantially decreased after therapy. The reductions were similar in responders to conventional therapy and non-responders (TNF alpha group). In conclusion, we found that MPV was correlated with inflammatory markers and disease activity in patients with RA. Both anti-TNF-alpha and conventional therapy decreases markers of inflammation and platelet indices. MPV can reflect both disease activity and response to treatment.</.
引用
收藏
页码:122 / 125
页数:4
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