Resistin is expressed in the human placenta

被引：139

作者：

Yura, S ^{[1
]}

Sagawa, N ^{[1
]}

Itoh, H ^{[1
]}

Kakui, K ^{[1
]}

Nuamah, MA ^{[1
]}

Korita, D ^{[1
]}

Takemura, M ^{[1
]}

Fujii, S ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Obstet & Gynecol, Sakyo Ku, Kyoto 6068507, Japan

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2003年 / 88卷 / 03期

关键词：

D O I：

10.1210/jc.2002-011926

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanism for decreased insulin sensitivity in pregnant women is not fully clarified. Resistin, a novel peptide hormone, is specifically expressed in the adipose tissue and decreases insulin sensitivity in rodents. In the present study, we demonstrate resistin gene expression in the human placental tissue, mainly in trophoblastic cells. The resistin gene expression in term placental tissue was more prominent than was seen in the first trimester chorionic tissue. In contrast resistin gene expression in adipose tissue was rather weak and remained unchanged by pregnancy. Thus, resistin is a newly isolated placental hormone in humans which may modulate insulin sensitivity during pregnancy.

引用

页码：1394 / 1397

页数：4

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