High Frequency of Antiphospholipid Antibodies in Primary Biliary Cirrhosis

被引：25

作者：

Mankai, Amani ^{[1
,2
]}

Manoubi, Wiem ^{[1
]}

Ghozzi, Mariam ^{[3
]}

Melayah, Sarra ^{[3
]}

Sakly, Wahiba ^{[1
,4
]}

Ghedira, Ibtissem ^{[1
,3
]}

机构：

[1] Monastir Univ, Res Unit UR 07 02 03, Fac Pharm, Monastir, Tunisia

[2] Tunis el Manar Univ, High Sch Sci & Tech Hlth, Tunis, Tunisia

[3] Farhat Hached Univ Hosp, Dept Immunol, Sousse 4000, Tunisia

[4] Gabes Univ, Fac Sci, Gabes, Tunisia

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2015年 / 29卷 / 01期

关键词：

primary biliary cirrhosis; antiphospholipid antibodies; anticardiolipin antibodies; anti-beta 2 glycoprotein I antibodies; Tunisia; SACCHAROMYCES-CEREVISIAE ANTIBODIES; ANTICARDIOLIPIN ANTIBODIES; ASSOCIATION; LIVER; DISEASE;

D O I：

10.1002/jcla.21723

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

AimTo evaluate, retrospectively, the frequency of autoantibodies of antiphospholipid syndrome (APLS) in Tunisian patients with primary biliary cirrhosis (PBC). Patients and methodsWe analyzed 80 PBC sera and 80 sera from blood donors. ELISA was used to determine the frequency of antibodies against cardiolipin (aCL IgG, IgA, and IgM) and beta 2 glycoprotein I (a2GPI IgG, IgA, and IgM). ResultsThe frequency of antiphospholipid antibodies (aCL and/or a2GPI) was significantly higher in PBC patients than in controls (70 vs. 5%, P < 10(-6)). The frequency of aCL antibodies (IgG, IgA or IgM) was significantly higher in PBC patients than in the control group (23.7 vs. 3.7%, P = 0.0005). The frequencies of aCL IgA and aCL IgM in PBC patients' sera were significantly higher than those in the control group (10 vs. 0%, P = 0.003 and 20 vs. 2.5%, P = 0.001, respectively). Two patients of eighty (2.5%) had aCL IgG, aCL IgA and aCL IgM. The frequency of a2GPI antibodies (IgG, IgA, or IgM) was significantly higher in PBC patients than in the control group (70 vs. 1.2%, P < 10(-6)). The frequencies of a2GPI IgG, a2GPI IgA, and a2GPI IgM in PBC patients' sera were significantly higher in patients than in the control group (12.5 vs. 0%, P = 0.003; 62.5 vs. 1.2%, P < 10(-6); and 21.2 vs. 0%, P < 10(-4), respectively). ConclusionAutoantibodies related to APLS (aCL and a2GPI) were present in the majority of patients with PBC, reflecting the ability of these antibodies to engage mediators of damage.

引用

页码：32 / 36

页数：5

共 32 条

[1]

Hyperplastic liver nodules associated with early-stage primary biliary cirrhosis mimicking hepatocellular carcinoma [J].