The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes

被引：52

作者：

Bosc, N ^{[1
]}

Lefranc, MP ^{[1
]}

机构：

[1] Univ Montpellier 2, IMGT, Immunogenet Mol Lab, Inst Genet Humaine,UPR 1142,CNRS, F-34396 Montpellier 5, France

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2003年 / 27卷 / 6-7期

关键词：

mouse; IMGT; T cell receptor alpha; T cell receptor delta; variable gene;

D O I：

10.1016/S0145-305X(03)00027-2

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

'The Mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes' 'IMGT Locus in Focus' report provides the first complete list of the mouse TRAV and TRDV genes which span 1550 kb on chromosome 14 at 19.7 cM. The total number of TRAV genes per haploid genome is 98 belonging to 23 subgroups. This includes 10 TRAV/DV genes which belong to seven subgroups. The functional TRAV genomic repertoire comprises 72-82 TRAV (including 9-10 TRAV/DV) belonging to 19 subgroups. The total number of TRDV genes per haploid genome is 16 (including the 10 TRAV/DV) belonging to 12 subgroups. The functional TRDV genomic repertoire comprises 14-15 genes (5 TRDV and 9-10 TRAV/DV) belonging to 11-12 subgroups. The eight tables and three figures of this report are available at the IMGT Marie-Paule page of IMGT. The international ImMunoGeneTics information system(R) (http://imgt.cines.fr) created by Marie-Paule Lefranc, Universite Montpellier II, CNRS, France. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：465 / 497

页数：33

共 130 条

[1] LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION [J].

ACHAORBEA, H ;

MITCHELL, DJ ;

TIMMERMANN, L ;

WRAITH, DC ;

TAUSCH, GS ;

WALDOR, MK ;

ZAMVIL, SS ;

MCDEVITT, HO ;

STEINMAN, L .

CELL, 1988, 54 (02) :263-273

[2] PREFERENTIAL USAGE OF V-ALPHA-4 AND V-BETA-10 T-CELL RECEPTOR GENES BY LYMPHOCYTIC CHORIOMENINGITIS VIRUS GLYCOPROTEIN-SPECIFIC H-2DB-RESTRICTED CYTOTOXIC T-CELLS [J].

AEBISCHER, T ;

OEHEN, S ;

HENGARTNER, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (03) :523-531

[3] DIVERSITY AND STRUCTURE OF GENES OF THE ALPHA-FAMILY OF MOUSE T-CELL ANTIGEN RECEPTOR [J].

ARDEN, B ;

KLOTZ, JL ;

SIU, G ;

HOOD, LE .

NATURE, 1985, 316 (6031) :783-787

[4]

Arden Bernhard, 1995, Immunogenetics, V42, P455

[5] The Telostei Immunoglobulin Light IGL1 and IGL2 V, J and C genes [J].

Artéro, S ;

Lefranc, MP .

EXPERIMENTAL AND CLINICAL IMMUNOGENETICS, 2000, 17 (03) :162-172

[6] The Teleostei Immunoglobulin Heavy IGH genes [J].

Artéro, S ;

Lefranc, MP .

EXPERIMENTAL AND CLINICAL IMMUNOGENETICS, 2000, 17 (03) :148-161

[7]

Azuara V, 1998, EUR J IMMUNOL, V28, P3456, DOI 10.1002/(SICI)1521-4141(199811)28:11&lt

[8]

3456::AID-IMMU3456&gt

[9]

3.0.CO

[10]

2-F

← 1 2 3 4 5 6 7 8 9 10 →