Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp.

被引：51

作者：

Barrow, CJ ^{[1
]}

Oleynek, JJ ^{[1
]}

Marinelli, V ^{[1
]}

Sun, HH ^{[1
]}

Kaplita, P ^{[1
]}

Sedlock, DM ^{[1
]}

Gillum, AM ^{[1
]}

Chadwick, CC ^{[1
]}

Cooper, R ^{[1
]}

机构：

[1] STERLING WINTHROP PHARMACEUT RES DIV,MALVERN,PA 19355

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 09期

关键词：

D O I：

10.7164/antibiotics.50.729

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A related group of compounds belonging to the antimycin class of antibiotics was found in culture, broth produced by a Streptomyces species. The group includes known antimycins A(1), A(2), A(3) and A(4), and new antimycins A(7) and A(8). These compounds inhibit ATP-citrate lyase with Ki values of 4 to 60 mu M against the substrate magnesium citrate. The structures-of the new antimycins were determined by spectroscopic analyses.

引用

页码：729 / 733

页数：5

共 13 条

[1] H-1 AND C-13 RESONANCE DESIGNATION OF ANTIMYCIN-A1 BY TWO-DIMENSIONAL NMR-SPECTROSCOPY [J].