Erythropoietin concentration in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis

被引:15
作者
Janik, P. [3 ]
Kwiecinski, H. [3 ]
Sokolowska, B. [2 ]
Niebroj-Dobosz, I. [1 ]
机构
[1] Polish Acad Sci, Inst Expt & Clin Med, Med Res Ctr, Neuromuscular Unit, PL-02106 Warsaw, Poland
[2] Polish Acad Sci, Inst Expt & Clin Med, Dept Resp Res, PL-02106 Warsaw, Poland
[3] Med Univ Warsaw, Dept Neurol, Warsaw, Poland
关键词
Amyotrophic lateral sclerosis; Erythropoietin; Cerebrospinal fluid; Serum; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; IN-VITRO; CORTICAL-NEURONS; MOUSE MODEL; PROTECTS; INJURY; DISEASE; ALS; NEUROPROTECTION;
D O I
10.1007/s00702-009-0354-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Erythropoietin (EPO) acts as a neuroprotective factor and is upregulated after neuronal injury. It has been reported that in cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients, the EPO concentration is decreased. In this study, EPO levels in serum and CSF of 30 patients with ALS and in 15 controls, using an ELISA technique, were estimated. EPO level in serum was decreased, especially in patients with bulbar onset ALS. A trend toward a progressive EPO decline with the duration of the disease in the mild + moderate ALS cases was observed. In severe cases, a tendency towards a positive correlation of EPO and duration of the disease was present. Serum EPO values were age related only in mild + moderate ALS in patients below 40 years of age. In CSF, the EPO levels were significantly decreased. Lower EPO values in the bulbar onset ALS when compared with the spinal onset ALS were present. The EPO decrease did not correlate with the severity and duration of the disease. Age relation of the EPO level only in the mild + moderate ALS cases more than 40 years was present. Lack of differences in EPO levels between patients with ALS of rapid and slow progression indicates that EPO concentration cannot be used as a prognostic factor. Nevertheless, the decreased serum and CSF EPO concentration and the known EPO neuroprotective action may indicate that EPO administration can be a new promising therapeutic approach in ALS.
引用
收藏
页码:343 / 347
页数:5
相关论文
共 34 条
[1]   The non-haematopoietic biological effects of erythropoietin [J].
Arcasoy, Murat O. .
BRITISH JOURNAL OF HAEMATOLOGY, 2008, 141 (01) :14-31
[2]   Cerebrospinal fluid erythropoietin (EPO) in amyotrophic lateral sclerosis [J].
Brettschneider, Johannes ;
Widl, Karin ;
Schattauer, Dagmar ;
Ludolph, Albert C. ;
Tumani, Hayrettin .
NEUROSCIENCE LETTERS, 2007, 416 (03) :257-260
[3]   Erythropoietin in the cerebrospinal fluid in neurodegenerative diseases [J].
Brettschneider, Johannes ;
Widl, Karin ;
Ehrenreich, Hannelore ;
Riepe, Matthias ;
Tumani, Hayrettin .
NEUROSCIENCE LETTERS, 2006, 404 (03) :347-351
[4]   Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury [J].
Brines, ML ;
Ghezzi, P ;
Keenan, S ;
Agnello, D ;
de Lanerolle, NC ;
Cerami, C ;
Itri, LM ;
Cerami, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10526-10531
[5]   El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis [J].
Brooks, BR ;
Miller, RG ;
Swash, M ;
Munsat, TL .
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS, 2000, 1 (05) :293-299
[6]   Erythropoietin and the brain: from neurodevelopment to neuroprotection [J].
Buemi, M ;
Cavallaro, E ;
Floccari, F ;
Sturiale, A ;
Aloisi, C ;
Trimarchi, M ;
Grasso, G ;
Corica, F ;
Frisina, N .
CLINICAL SCIENCE, 2002, 103 (03) :275-282
[7]   Regenerative Medicine: Does Erythropoietin have a Role? [J].
Buemi, Michele ;
Lacquaniti, Antonio ;
Maricchiolo, Giulia ;
Bolignano, Davide ;
Campo, Susanna ;
Cernaro, Valeria ;
Sturiale, Alessio ;
Grasso, Giovanni ;
Buemi, Antoine ;
Allegra, Alessandro ;
Donato, Valentina ;
Genovese, Lucrezia .
CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (17) :2026-2036
[8]   Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation [J].
Calapai, G ;
Marciano, MC ;
Corica, F ;
Allegra, A ;
Parisi, A ;
Frisina, N ;
Caputi, AP ;
Buemi, M .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 401 (03) :349-356
[9]   Enhanced expression of erythropoietin in the central nervous system of SOD1G93A transgenic mice [J].
Chung, YH ;
Joo, KM ;
Kim, YS ;
Lee, KH ;
Lee, WB ;
Cha, CI .
BRAIN RESEARCH, 2004, 1016 (02) :272-280
[10]   Erythropoietin:: Novel approaches to neuroprotection in human brain disease [J].
Ehrenreich, H ;
Aust, C ;
Krampe, H ;
Jahn, H ;
Jacob, S ;
Herrmann, M ;
Sirén, AL .
METABOLIC BRAIN DISEASE, 2004, 19 (3-4) :195-206