Post-trauma administration of caffeine plus ethanol reduces contusion volume and improves working memory in rats

被引:19
作者
Dash, PK
Moore, AN
Moody, MR
Treadwell, R
Felix, JL
Clifton, GL
机构
[1] Univ Texas, Sch Med, Smith Ctr Neurol Res, Dept Neurobiol, Houston, TX 77225 USA
[2] Univ Texas, Sch Med, Smith Ctr Neurol Res, Dept Anat, Houston, TX 77225 USA
关键词
caffeinol; combination therapy; hippocampus; prefrontal cortex; trace fear conditioning; working memory;
D O I
10.1089/0897715042441828
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
It has been demonstrated that ethanol exerts dose-dependent effects, both beneficial and detrimental, on the outcome of traumatic brain injury (TBI). Recently, it has been reported that co-administration of caffeine (10 mg/kg) and a low amount of alcohol (0.65 g/kg; caffeinol) reduces cortical infarct volume up to 80%, and improves motor coordination, following a rodent model of reversible common carotid/middle cerebral artery occlusion. However, the protective effects of caffeinol following other CNS insults, nor its influence on cognitive function, have been examined. Using a controlled cortical impact model of brain injury, the effect of caffeinol administration on TBI-associated motor and cognitive deficits was assessed. When given 15 min following injury, caffeinol reduced cortical tissue loss and improved working memory. However, no influence on motor skills, Morris water maze performance or associative learning and memory was observed. Delayed administration (6 h post-injury) of caffeinol containing a dose of ethanol (I g/kg) previously demonstrated to improve motor performance eliminated the working memory benefit and cortical protection. These results indicate that early administration of caffeinol may be beneficial in lessening some of the deficits and cortical tissue loss associated with brain trauma.
引用
收藏
页码:1573 / 1583
页数:11
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