Cardiac Adaptive Responses After Hypoxia in an Experimental Model

被引：14

作者：

Bin-Jaliah, Ismaeel ^{[1
]}

Ammar, Hania I. ^{[2
]}

Mikhailidis, Dimitri P. ^{[4
]}

Dallak, Mohammed A. ^{[1
]}

Al-Hashem, Fahaid H. ^{[1
]}

Haidara, Mohamed A. ^{[1
]}

Yassin, Hanaa Z. ^{[2
]}

Bahnasi, Abeer A. ^{[3
]}

Rashed, Laila A.

Isenovic, Esma R. ^{[5
]}

机构：

[1] King Khalid Univ, Dept Physiol, Coll Med, Abha, Saudi Arabia

[2] Cairo Univ, Dept Physiol, Kasr Al Aini Fac Med, Cairo, Egypt

[3] Cairo Univ, Dept Pathol, Natl Canc Inst, Cairo, Egypt

[4] UCL, Dept Clin Biochem, Vasc Dis Prevent Clin, Univ Coll London Med Sch, London WC1E 6BT, England

[5] Univ Belgrade, Vinca Inst, Belgrade, Serbia

来源：

ANGIOLOGY | 2010年 / 61卷 / 02期

关键词：

acute intermittent hypoxia; hypoxic preconditioning; vascular endothelial growth factor; erythropoietin; ENDOTHELIAL GROWTH-FACTOR; INTERMITTENT HYPOXIA; RAT MYOCARDIUM; HIGH-ALTITUDE; LATE-PHASE; ERYTHROPOIETIN; ISCHEMIA; EXPRESSION; PROTECTION; STRESS;

D O I：

10.1177/0003319709352486

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P<.001), RPP (P<.001), and Delta P/Delta t(max) (P<.001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms.

引用

页码：145 / 156

页数：12

共 58 条

[1] Acute intermittent hypoxia improves rat myocardium tolerance to ischemia [J].

Béguin, PC ;

Joyeux-Faure, M ;

Godin-Ribuot, D ;

Lévy, P ;

Ribuot, C .

JOURNAL OF APPLIED PHYSIOLOGY, 2005, 99 (03) :1064-1069

[2] The late phase of preconditioning [J].

Bolli, R .

CIRCULATION RESEARCH, 2000, 87 (11) :972-983

[3]

Bolli R, 1996, BASIC RES CARDIOL, V91, P57

[4] Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury [J].

Cai, ZQ ;

Semenza, GL .

CIRCULATION, 2004, 109 (17) :2050-2053

[5] Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury [J].

Cai, ZQ ;

Manalo, DJ ;

Wei, G ;

Rodriguez, ER ;

Fox-Talbot, K ;

Lu, HS ;

Zweier, JL ;

Semenza, GL .

CIRCULATION, 2003, 108 (01) :79-85

[6] Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression [J].

Dong, JW ;

Zhu, HF ;

Zhu, WZ ;

Ding, HL ;

Ma, TM ;

Zhou, ZN .

CELL RESEARCH, 2003, 13 (05) :385-391

[7]

ENGELMAN DT, 1995, CARDIOVASC RES, V29, P133, DOI 10.1016/0008-6363(96)88558-0

[8]

Fisher JW, 2003, EXP BIOL MED, V228, P1

[9] ROLE OF THE FLT-1 RECEPTOR TYROSINE KINASE IN REGULATING THE ASSEMBLY OF VASCULAR ENDOTHELIUM [J].

FONG, GH ;

ROSSANT, J ;

GERTSENSTEIN, M ;

BREITMAN, ML .

NATURE, 1995, 376 (6535) :66-70

[10]

Hashimoto Etsuo, 1994, American Journal of Physiology, V267, pH1948

← 1 2 3 4 5 6 →