Cardiac Adaptive Responses After Hypoxia in an Experimental Model

被引:14
作者
Bin-Jaliah, Ismaeel [1 ]
Ammar, Hania I. [2 ]
Mikhailidis, Dimitri P. [4 ]
Dallak, Mohammed A. [1 ]
Al-Hashem, Fahaid H. [1 ]
Haidara, Mohamed A. [1 ]
Yassin, Hanaa Z. [2 ]
Bahnasi, Abeer A. [3 ]
Rashed, Laila A.
Isenovic, Esma R. [5 ]
机构
[1] King Khalid Univ, Dept Physiol, Coll Med, Abha, Saudi Arabia
[2] Cairo Univ, Dept Physiol, Kasr Al Aini Fac Med, Cairo, Egypt
[3] Cairo Univ, Dept Pathol, Natl Canc Inst, Cairo, Egypt
[4] UCL, Dept Clin Biochem, Vasc Dis Prevent Clin, Univ Coll London Med Sch, London WC1E 6BT, England
[5] Univ Belgrade, Vinca Inst, Belgrade, Serbia
关键词
acute intermittent hypoxia; hypoxic preconditioning; vascular endothelial growth factor; erythropoietin; ENDOTHELIAL GROWTH-FACTOR; INTERMITTENT HYPOXIA; RAT MYOCARDIUM; HIGH-ALTITUDE; LATE-PHASE; ERYTHROPOIETIN; ISCHEMIA; EXPRESSION; PROTECTION; STRESS;
D O I
10.1177/0003319709352486
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P<.001), RPP (P<.001), and Delta P/Delta t(max) (P<.001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms.
引用
收藏
页码:145 / 156
页数:12
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