Priming of alloreactive T cells - where does it happen?

被引：8

作者：

Golshayan, D ^{[1
]}

Lechler, R ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Dept Immunol, London W12 0NN, England

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2004年 / 34卷 / 12期

关键词：

transplantation; allorecognition; direct and indirect pathways;

D O I：

10.1002/eji.200425506

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Host lymphocytes can recognize alloantigens directly on transplanted donor tissue or indirectly after these antigens are processed and presented on host APC. Here, we outline the features of alloresponses that distinguish them from responses to conventional antigens, then we discuss various study systems that have examined where the priming of alloreactive CD4(+) and CD8(+) T cells occurs. Finally, we discuss the implications of recent data which suggest that direct responses originate in the graft itself whereas indirect responses are initiated in the draining lymph nodes.

引用

收藏

页码：3301 / 3304

页数：4

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