Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection

被引：6

作者：

Fukatsu, K ^{[1
]}

Saito, H ^{[1
]}

Fukushima, R ^{[1
]}

Lin, MT ^{[1
]}

Inoue, T ^{[1
]}

Inaba, T ^{[1
]}

Furukawa, S ^{[1
]}

Han, L ^{[1
]}

Muto, T ^{[1
]}

机构：

[1] UNIV TOKYO,SURG CTR,BUNKYO KU,TOKYO 113,JAPAN

来源：

INFLAMMATION RESEARCH | 1996年 / 45卷 / 03期

关键词：

N-G-nitro-L-arginine-methyl-ester (L-NAME); N-G-monomethyl-L-arginine (L-NMMA); N-iminoethyl-L-ornithine (L-NIO); septic shock; survival;

D O I：

10.1007/BF02265161

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To examine the effects of three nitric oxide synthase inhibitors on survival in a murine sepsis model. Design: Prospective randomized experimental trials. Setting: Prospective randomized experimental trials. Setting: Laboratory. Subjects: Female Balb/c mice. Interventions: Escherichia coli (10(8) colony-forming-units/body) were injected into the peritoneal cavities of Balb/c mice. N-G-nitro-L-arginine-methyl-ester, N-G-monomethyl-L-arginine, or N-iminoethyl-L-ornithine was given at various concentrations, intraperitoneally, one hour before bacterial challenge. Measurements: One hundred and fifteen animals were observed for survival. Results: These inhibitors provided the mice no protection from the bacterial challenge. Notably, pretreatment with N-G-nitro-L-arginine-Methyl-ester (100 mg/kg i.p.) actually reduced survival time after E. coli challenge. Conclusions: Inhibition of nitric oxide production improved neither the survival time nor rate in this murine sepsis model.

引用

页码：109 / 112

页数：4

共 17 条

[1] INHIBITION OF NITRIC-OXIDE SYNTHASE IN EXPERIMENTAL GRAM-NEGATIVE SEPSIS [J].