The role of NFAT5/TonEBP in establishing an optimal intracellular environment

被引：60

作者：

Ho, SN

机构：

[1] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 413卷 / 02期

关键词：

NFAT; NFAT5; TonEBP; hypertonicity; cell volume; cell size; intracellular environment; cell growth; transcription;

D O I：

10.1016/S0003-9861(03)00130-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NFAT5/TonEBP, the most recently described member of the rel/NFkappaB/NFAT family of signal-dependent transcription factors, is activated by extracellular hypertonicity-a cellular stress of particular and perhaps unique physiologic relevance to cells of the renal medulla. Accumulating evidence suggests that NFAT5/TonEBP also functions in vivo under isotonic conditions as part of a ubiquitous regulatory mechanism that senses and adjusts available intracellular volume during cell growth to establish an intracellular environment appropriate for optimal cell proliferation. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：151 / 157

页数：7

共 57 条

[1] Macromolecular crowding and its role as intracellular signalling of cell volume regulation [J].