HAP1 and intracellular trafficking

被引：64

作者：

Li, XJ ^{[1
]}

Li, SH ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 01期

关键词：

D O I：

10.1016/j.tips.2004.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Huntington's disease is caused by a polyglutamine expansion in the protein huntingtin. Several studies suggest that huntingtin and its associated protein HAP1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study now provides new evidence that HAP1 is also involved in the endocytosis of membrane receptors. These studies offer insight into the normal function of HAP1 and its involvement in Huntington's disease.

引用

页码：1 / 3

页数：3

共 26 条

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