IL-10 Inhibits miR-155 Induction by Toll-like Receptors

被引：211

作者：

McCoy, Claire E. ^{[1
]}

Sheedy, Frederick J. ^{[1
]}

Qualls, Joseph E. ^{[2
]}

Doyle, Sarah L. ^{[1
]}

Quinn, Susan R. ^{[1
]}

Murray, Peter J. ^{[2
]}

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

[2] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 27期

基金：

爱尔兰科学基金会;

关键词：

DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE; B-CELL LYMPHOMAS; IMMUNE-RESPONSE; TRANSGENIC MICE; EXPRESSION; MICRORNA; TARGET; TRANSCRIPTION; ACTIVATION; PATHWAY;

D O I：

10.1074/jbc.M110.102111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes, which are induced by Toll-like receptor (TLR) signaling. In this study, we have examined whether modulation of microRNAs plays a role in the inhibitory effect of IL-10 on TLR4 signaling. Analyzing microRNAs known to be induced by TLR4, we found that IL-10 could inhibit the expression of miR-155 in response to lipopolysaccharide but had no effect on miR-21 or miR-146a. IL-10 inhibited miR-155 transcription from the BIC gene in a STAT3-dependent manner. This inhibitory effect of IL-10 on miR-155 led to an increase in the expression of the miR-155 target, SHIP1. This is the first example of IL-10 playing a role in microRNA function and suggests that through its inhibitory effect on miR-155, IL-10 has the ability to promote anti-inflammatory gene expression.

引用

页码：20492 / 20498

页数：7

共 33 条

[1] Src homology 2 domain-containing inositol-5-phosphatase 1 (SITP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism [J].

An, HZ ;

Xu, HM ;

Zhang, MH ;

Zhou, J ;

Feng, T ;

Qian, C ;

Qi, RZ ;

Cao, XT .

BLOOD, 2005, 105 (12) :4685-4692

[2] Interleukin-10 therapy - Review of a new approach [J].

Asadullah, K ;

Sterry, W ;

Volk, HD .

PHARMACOLOGICAL REVIEWS, 2003, 55 (02) :241-269

[3] Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice [J].

Costinean, S ;

Zanesi, N ;

Pekarsky, Y ;

Tili, E ;

Volinia, S ;

Heerema, N ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7024-7029

[4] Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice [J].

Costinean, Stefan ;

Sandhu, Sukhinder K. ;

Pedersen, Irene M. ;

Tili, Esmerina ;

Trotta, Rossana ;

Perrotti, Danilo ;

Ciarlariello, David ;

Neviani, Paolo ;

Harb, Jason ;

Kauffman, Lauren Rachel ;

Shidham, Aaditya ;

Croce, Carlo Maria .

BLOOD, 2009, 114 (07) :1374-1382

[5] Accumulation of miR-155 and BIC RNA in human B cell lymphomas [J].

Eis, PS ;

Tam, W ;

Sun, LP ;

Chadburn, A ;

Li, ZD ;

Gomez, MF ;

Lund, E ;

Dahlberg, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) :3627-3632

[6] Cutting edge:: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway [J].

El Kasmi, Karim C. ;

Smith, Amber M. ;

Williams, Lynn ;

Neale, Geoffrey ;

Panopolous, Athanasia ;

Watowich, Stephanie S. ;

Haecker, Hans ;

Toxwell, Brian M. J. ;

Murray, Peter J. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (11) :7215-7219

[7] miR-155 gene: A typical multifunctional microRNA [J].

Faraoni, Isabella ;

Antonetti, Francesca Romana ;

Cardone, John ;

Bonmassar, Enzo .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2009, 1792 (06) :497-505

[8] Fine-tuning of the innate immune response by microRNAs [J].

Gantier, Michael P. ;

Sadler, Anthony J. ;

Williams, Bryan Rg .

IMMUNOLOGY AND CELL BIOLOGY, 2007, 85 (06) :458-462

[9] New Perspectives in MicroRNA Regulation of Innate Immunity [J].

Gantier, Michael P. .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2010, 30 (05) :283-289

[10] A role for microRNAs in the development of the immune system and in the pathogenesis of cancer [J].

Kanellopoulou, Chryssa ;

Monticelli, Silvia .

SEMINARS IN CANCER BIOLOGY, 2008, 18 (02) :79-88

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