Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium

被引：89

作者：

Sugiyama, M

Bhawal, UK

Dohmen, T

Ono, S

Miyauchi, M

Ishikawa, T

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Oral & Maxillofacial Surg, Div Cervicognathostomatol Minami Ku, Hiroshima 7348553, Japan

[2] Hiroshima Univ, Dent Hosp, Hiroshima 730, Japan

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2003年 / 95卷 / 05期

关键词：

D O I：

10.1067/moe.2003.36

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. Our aim was to clarify the association of human papillomavirus (HPV) with oral carcinogenesis, especially its early stage. Study design. Tissue specimens of normal mucosa, epithelial dysplasia, oral squamous cell carcinoma (OSCC), and OSCC cell lines were examined for the presence of HPV-16 and HPV-18 E6 DNA by means of the polymerase chain reaction test. Results. The detection rate of HPV-16 in epithelial dysplasia (31/51) was higher than that in normal mucosa (16/44) and in OSCC (30/86) and was statistically different from that in OSCC. The cases that progressed from epithelia[ dysplasia to carcinoma showed a significantly higher HPV-16 detection rate than the other cases in both epithelial dysplasia and OSCC. HPV-16 and HPV-18 were detected only at early passages of 2 of 10 OSCC cell lines. Conclusion. These results strongly suggest that HPV-16 may be involved in the early stages of the development of some oral carcinomas.

引用

页码：594 / 600

页数：7

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