Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia

被引:295
作者
Kasai, K
Shenton, ME
Salisbury, DF
Hirayasu, Y
Lee, CU
Ciszewski, AA
Yurgelun-Todd, D
Kikinis, R
Jolesz, FA
McCarley, RW
机构
[1] Harvard Univ, Sch Med, Brockton Div,Lab Neurosci,Clin Neurosci Div, Boston VA Healthcare Syst,Dept Psychiat 116A, Brockton, MA 02301 USA
[2] Brigham & Womens Hosp, MRI Div, Surg Planning Lab, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA
[4] McLean Hosp, Cognit Neurosci Lab, Belmont, MA 02178 USA
关键词
D O I
10.1176/appi.ajp.160.1.156
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Smaller temporal lobe cortical gray matter volumes, including the left superior temporal gyrus, have been reported in magnetic resonance imaging (MRI) studies of patients with chronic schizophrenia and, more recently, in patients with first-episode schizophrenia. However, it remains unknown whether there are progressive decreases in temporal lobe cortical gray matter volumes in patients with first-episode schizophrenia and whether similarly progressive volume decreases are present in patients with affective psychosis. Method: High-spatial-resolution MRI scans at initial hospitalization and 1.5 years later were obtained from 13 patients with first-episode schizophrenia, 15 patients with first-episode affective psychosis (mainly manic), and 14 healthy comparison subjects. MRI volumes were calculated for gray matter of superior temporal gyrus and for the amygdala-hippocampal complex. Results: Patients with first-episode schizophrenia showed significant decreases in gray matter volume over time in the left superior temporal gyrus compared with patients with first-episode affective psychosis or healthy comparison subjects. This progressive decrease was more pronounced in the posterior portion of the left superior temporal gyrus (mean=9.6%) than in the anterior portions (mean=8.4%). No group differences in the rate of change over time were present in other regions. Conclusions: These findings demonstrate a progressive volume reduction of the left posterior superior temporal gyrus gray matter in patients with first-episode schizophrenia but not in patients with first-episode affective psychosis.
引用
收藏
页码:156 / 164
页数:9
相关论文
共 29 条
[11]   A follow-up magnetic resonance imaging study of schizophrenia -: Relationship of neuroanatomical changes to clinical and neurobehavioral measures [J].
Gur, RE ;
Cowell, P ;
Turetsky, BI ;
Gallacher, F ;
Cannon, T ;
Bilker, W ;
Gur, RC .
ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (02) :145-152
[12]   Planum temporale and Heschl gyrus volume reduction in schizophrenia -: A magnetic resonance imaging study of first-episode patients [J].
Hirayasu, Y ;
McCarley, RW ;
Salisbury, DF ;
Tanaka, S ;
Kwon, JS ;
Frumin, M ;
Snyderman, D ;
Yurgelun-Todd, D ;
Kikinis, R ;
Jolesz, FA ;
Shenton, ME .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (07) :692-699
[13]   Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects [J].
Hirayasu, Y ;
Shenton, ME ;
Salisbury, DF ;
Dickey, CC ;
Fischer, IA ;
Mazzoni, P ;
Kisler, T ;
Arakaki, H ;
Kwon, JS ;
Anderson, JE ;
Yurgelun-Todd, D ;
Tohen, M ;
McCarley, RW .
AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (10) :1384-1391
[14]   Progressive reduction of temporal lobe structures in childhood-onset schizophrenia [J].
Jacobsen, LK ;
Giedd, JN ;
Castellanos, FX ;
Vaituzis, AC ;
Hamburger, SD ;
Kumra, S ;
Lenane, MC ;
Rapoport, JL .
AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (05) :678-685
[15]   Superior temporal gyrus and the course of early schizophrenia: progressive, static, or reversible? [J].
Keshavan, MS ;
Haas, GL ;
Kahn, CE ;
Aguilar, E ;
Dick, EL ;
Schooler, NR ;
Sweeney, JA ;
Pettegrew, JW .
JOURNAL OF PSYCHIATRIC RESEARCH, 1998, 32 (3-4) :161-167
[16]   Longitudinal study of brain morphology in first episode schizophrenia [J].
Lieberman, J ;
Chakos, M ;
Wu, HW ;
Alvir, J ;
Hoffman, E ;
Robinson, D ;
Bilder, R .
BIOLOGICAL PSYCHIATRY, 2001, 49 (06) :487-499
[17]   Progressive brain volume changes and the clinical course of schizophrenia in men - A longitudinal magnetic resonance imaging study [J].
Mathalon, DH ;
Sullivan, EV ;
Lim, KO ;
Pfefferbaum, A .
ARCHIVES OF GENERAL PSYCHIATRY, 2001, 58 (02) :148-157
[18]   P300 reduction and prolongation with illness duration in schizophrenia [J].
Mathalon, DH ;
Ford, JM ;
Rosenbloom, M ;
Pfefferbaum, A .
BIOLOGICAL PSYCHIATRY, 2000, 47 (05) :413-427
[19]   MRI anatomy of schizophrenia [J].
McCarley, RW ;
Wible, CG ;
Frumin, M ;
Hirayasu, Y ;
Levitt, JJ ;
Fischer, IA ;
Shenton, ME .
BIOLOGICAL PSYCHIATRY, 1999, 45 (09) :1099-1119
[20]   Neuroimaging and the cognitive neuroscience of schizophrenia [J].
McCarley, RW ;
Hsiao, JK ;
Freedman, R ;
Pfefferbaum, A ;
Donchin, E .
SCHIZOPHRENIA BULLETIN, 1996, 22 (04) :703-725