Insulin resistance and type 2 diabetes -: An adipocentric view

被引:22
作者
Cederberg, A [1 ]
Enerbäck, S [1 ]
机构
[1] Univ Gothenburg, Dept Med Biochem, SE-40530 Gothenburg, Sweden
关键词
D O I
10.2174/1566524033361573
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
As a result of selecting triglycerides as the major vehicle for storing superfluous energy, evolution came up with a specialized cell type, the adipocyte, equipped to handle triglycerides and its potentially toxic metabolites - fatty acids. For the first time in history large human populations are subjected a wealth of cheap, accessible and palatable calories. This has created a situation, on a large scale not previously encountered, in which the capacity to store triglycerides in adipocytes is an important determinant of human health. Too few adipocytes (e.g. lipodystrophia) or a situation in which all adipocytes are filled, to their maximum capacity (e.g. severe obesity), will create very similar and unfavorable metabolic situations in which ectopic triglyceride stores will appear in tissues like liver and muscle. This review sets out to discuss the adipocyte and its role in metabolism as well as the consequences of a metabolic situation, in which the adipocyte has lost its fat storing monopoly.
引用
收藏
页码:107 / 125
页数:19
相关论文
共 221 条
  • [1] Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    Abel, ED
    Peroni, O
    Kim, JK
    Kim, YB
    Boss, O
    Hadro, E
    Minnemann, T
    Shulman, GI
    Kahn, BB
    [J]. NATURE, 2001, 409 (6821) : 729 - 733
  • [2] Activators of peroxisome proliferator-activated receptor γ have depot-specific effects on human preadipocyte differentiation
    Adams, M
    Montague, CT
    Prins, JB
    Holder, JC
    Smith, SA
    Sanders, L
    Digby, JE
    Sewter, CP
    Lazar, MA
    Chatterjee, VKK
    O'Rahilly, S
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (12) : 3149 - 3153
  • [3] Role of leptin in the neuroendocrine response to fasting
    Ahima, RS
    Prabakaran, D
    Mantzoros, C
    Qu, DQ
    Lowell, B
    MaratosFlier, E
    Flier, JS
    [J]. NATURE, 1996, 382 (6588) : 250 - 252
  • [4] Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents
    Ahuja, HS
    Liu, S
    Crombie, DL
    Boehm, M
    Leibowitz, MD
    Heyman, RA
    Depre, C
    Nagy, L
    Tontonoz, P
    Davies, PJA
    [J]. MOLECULAR PHARMACOLOGY, 2001, 59 (04) : 765 - 773
  • [5] Compensatory regulation of RI alpha protein levels in protein kinase A mutant mice
    Amieux, PS
    Cummings, DE
    Motamed, K
    Brandon, EP
    Wailes, LA
    Le, K
    Idzerda, RL
    McKnight, GS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) : 3993 - 3998
  • [6] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    Arita, Y
    Kihara, S
    Ouchi, N
    Takahashi, M
    Maeda, K
    Miyagawa, J
    Hotta, K
    Shimomura, I
    Nakamura, T
    Miyaoka, K
    Kuriyama, H
    Nishida, M
    Yamashita, S
    Okubo, K
    Matsubara, K
    Muraguchi, M
    Ohmoto, Y
    Funahashi, T
    Matsuzawa, Y
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) : 79 - 83
  • [7] Regulation by glucocorticoids of angiotensinogen gene expression and secretion in adipose cells
    Aubert, J
    Darimont, C
    Safonova, I
    Ailhaud, G
    Negrel, R
    [J]. BIOCHEMICAL JOURNAL, 1997, 328 : 701 - 706
  • [8] PPARγ is required for placental, cardiac, and adipose tissue development
    Barak, Y
    Nelson, MC
    Ong, ES
    Jones, YZ
    Ruiz-Lozano, P
    Chien, KR
    Koder, A
    Evans, RM
    [J]. MOLECULAR CELL, 1999, 4 (04) : 585 - 595
  • [9] Insulin stimulates both leptin secretion and production by rat white adipose tissue
    Barr, VA
    Malide, D
    Zarnowski, MJ
    Taylor, SI
    Cushman, SW
    [J]. ENDOCRINOLOGY, 1997, 138 (10) : 4463 - 4472
  • [10] Genetics of body-weight regulation
    Barsh, GS
    Farooqi, IS
    O'Rahilly, S
    [J]. NATURE, 2000, 404 (6778) : 644 - 651