Recent discoveries in vasopressin-regulated aquaporin-2 trafficking

被引:22
作者
Fenton, Robert A. [1 ]
Moeller, Hanne B. [1 ]
机构
[1] Univ Aarhus, Water & Salt Res Ctr, Inst Anat, Aarhus, Denmark
来源
ADVANCES IN VASOPRESSIN AND OXYTOCIN: FROM GENES TO BEHAVIOUR TO DISEASE | 2008年 / 170卷
基金
新加坡国家研究基金会;
关键词
aquaporin/s; urinary concentrating mechanism; microtubule; actin; PKA; phosphorylation;
D O I
10.1016/S0079-6123(08)00444-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the kidney, the actions of the antidiuretic hormone arginine vasopressin (AVP) renders the collecting duct highly permeable to water. This large increase in water permeability is largely due to the translocation of the water channel aquaporin-2 (AQP-2) from intracellular storage vesicles to the apical plasma membrane of collecting duct principal cells. The focus of this chapter is on the recent advances in interpreting the complex mechanism that causes regulated exocytosis of AQP-2 to the apical plasma membrane, its regulated endocytosis and the recycling of AQP-2. Determining how AQP-2 trafficking occurs at the molecular level is fundamental to understanding the physiology of water balance regulation and the pathophysiology of water balance disorders.
引用
收藏
页码:571 / 579
页数:9
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