Trafficking of UL37 Proteins into Mitochondrion-Associated Membranes during Permissive Human Cytomegalovirus Infection

被引：32

作者：

Bozidis, Petros ^{[1
]}

Williamson, Chad D. ^{[1
,2
]}

Wong, Daniel S. ^{[1
]}

Colberg-Poley, Anamaris M. ^{[1
,2
,3
]}

机构：

[1] Childrens Natl Med Ctr, Ctr Canc & Immunol Res, Childrens Res Inst, Washington, DC 20010 USA

[2] George Washington Univ, Dept Biochem & Mol Biol, Washington, DC 20037 USA

[3] George Washington Univ, Sch Med & Hlth Sci, Dept Pediat, Washington, DC 20037 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 15期

关键词：

ENDOPLASMIC-RETICULUM; LOCALIZED INHIBITOR; INDUCED APOPTOSIS; CYTOCHROME B(5); GENE-EXPRESSION; CALCIUM; VMIA; BAX; GLYCOPROTEIN; SIGNAL;

D O I：

10.1128/JVI.00885-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human cytomegalovirus (HCMV) UL37 proteins traffic sequentially from the endoplasmic reticulum (ER) to the mitochondria. In transiently transfected cells, UL37 proteins traffic into the mitochondrion-associated membranes (MAM), the site of contact between the ER and mitochondria. In HCMV-infected cells, the predominant UL37 exon 1 protein, pUL37x1, trafficked into the ER, the MAM, and the mitochondria. Surprisingly, a component of the MAM calcium signaling junction complex, cytosolic Grp75, was increasingly enriched in heavy MAM from HCMV-infected cells. These studies show the first documented case of a herpesvirus protein, HCMV pUL37x1, trafficking into the MAM during permissive infection and HCMV-induced alteration of the MAM protein composition.

引用

页码：7898 / 7903

页数：6

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