Synthesis of a new family of glycolipidic nitrones as potential antioxidant drugs for neurodegenerative disorders

被引：36

作者：

Durand, G

Polidori, A

Salles, JP

Pucci, B

机构：

[1] Fac Sci Avignon, Lab Chim BioOrgan & Syst Mol Vectoriels, F-84000 Avignon, France

[2] Targeting Syst Pharma, F-13510 Eguilles, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(02)01079-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper deals with the synthesis of a novel series of amphiphilic glycosylated spin-traps derived from alpha-Phenyl-N-tert-butyl nitrone (PBN) and an initial characterization of their anti-caspase-3 activity. Preliminary investigation of their anti-apoptosis effect showed they dramatically inhibit the activity of caspase-3 in cultured neuronal cells following induction of apoptosis by hydrogen peroxide. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：859 / 862

页数：4

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