Aza-Baylis-Hillman reaction of β-substituted activated olerins with N-tosyl imines

被引:41
作者
Shi, YL [1 ]
Xu, YM [1 ]
Shi, M [1 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
关键词
aza-Baylis-Hillman reaction; enones; Lewis base catalyst; organic catalysis; phosphanes; N-tosyl imines;
D O I
10.1002/adsc.200404045
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Aza-Baylis-Hillman reactions of P-substituted activated olefins such as crotonaldehyde, (E)propenyl phenyl ketone, hex-2-enal or pent-3-en-2-one with N-tosyl imines can be carried out for the first time in the presence of tertiary phosphine Lewis bases such as PPh2Me or PPhMe2 to give the corresponding Baylis-Hillman adducts in moderate to good yields under mild reaction conditions.
引用
收藏
页码:1220 / 1230
页数:11
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