Cobalt catalysed hydro-sulfenylation of Michael acceptors

被引：9

作者：

Friend, CL

Simpkins, NS

Anson, M

Polywka, MEC

机构：

[1] Univ Nottingham, Dept Chem, Nottingham NG7 2RD, England

[2] Glaxo Wellcome Res & Dev Ltd, Stevenage SG1 2NY, Herts, England

[3] Oxford Asymmetry Ltd, Abingdon OX14 4SD, Oxon, England

来源：

TETRAHEDRON | 1998年 / 54卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(98)83016-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of certain types of Michael accepters, limited to those having methylene groups, with a mixture of diphenyl disulfide and phenyl silane, under the influence of 10% of the cobalt catalyst, Co(eobe) 3, results in the formation of hydro-sulfenylated products, such as alpha-phenylthio carbonyl compounds, in moderate to good yields. The process involves intermediates having radical character, judging by the 5-exo-trig cyclisation product 21 observed in the reaction of alpha,beta-unsaturated ester 20 having a suitable unsaturated sidechain. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2801 / 2808

页数：8

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