Evidence for an octanoate synthase operating during the biosynthesis of piliformic acid in Poronia piliformis

被引：8

作者：

Culceth, H ^{[1
]}

Fuchser, J ^{[1
]}

Moss, SJ ^{[1
]}

Nieschalk, J ^{[1
]}

O'Hagan, D ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, Sci Labs, Durham DH1 3LE, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(98)00102-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sodium [1-C-13]-octanoate is incorporated intact into the C-8 unit of piliformic acid 1 in Poronia piliformis whereas sodium [3-C-13]-decanoate 2 is incorporated into this unit only after prior beta-oxidation to [1-C-13]-acetyl-CoA. Also 8-fluoraoctanaote 3 is utilised by P. piliformis as an intact unit to generate 9-fluoropiliformic acid 5 whereas 10-fluorodecanoate 4 is not. These results suggest that octanoate is biosynthesised de novo for secondary metabolism and is not assimilated from higher fatty acids by beta-oxidation. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1949 / 1952

页数：4

共 14 条

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