The highways and byways of mRNA decay

被引：1005

作者：

Garneau, Nicole L.

Wilusz, Jeffrey

Wilusz, Carol J. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

[2] Colorado State Univ, Cellular & Mol Biol Program, Ft Collins, CO 80523 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2104

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

When considering the control of gene expression, the focus has traditionally been on transcriptional regulation. Recently, however, the large contribution made by mRNA decay has become difficult to ignore. Large-scale analyses indicate that as many as half of all changes in the amounts of mRNA in some responses can be attributed to altered rates of decay. In this article, we discuss some of the mechanisms that are used by the cell to mediate and regulate this intriguing process.

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收藏

页码：113 / 126

页数：14

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