Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export

被引：220

作者：

Tseng, SSL

Weaver, PL

Liu, Y

Hitomi, M

Tartakoff, AM

Chang, TH ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[2] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Cell Biol Program, Cleveland, OH 44106 USA

来源：

EMBO JOURNAL | 1998年 / 17卷 / 09期

关键词：

ATPase; DEAD-box protein; mRNA export; RNA helicase;

D O I：

10.1093/emboj/17.9.2651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae, It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated [poly(A)(+)] RNA export. Surprisingly, Dbp5p is present predominantly, if not exclusively, in the cytoplasm, and is highly enriched around the nuclear envelope. This observation raises the possibility that Dbp5p may play a role in unloading or remodeling messenger RNA particles (mRNPs) upon arrival in the cytoplasm and in coupling mRNP export and translation. The functions of Dbp5p are likely to be conserved, since its potential homologues can be found in a variety of eukaryotic cells.

引用

页码：2651 / 2662

页数：12

共 67 条

[41] A distinct and parallel pathway for the nuclear import of an mRNA-binding protein [J].