Changes in the concentration of plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) after total joint replacement in patients with arthritis

被引：16

作者：

Omura, K

Takahashi, M

Omura, T

Miyamoto, S

Kushida, K

Sano, Y

Miura, M

Nagano, A

机构：

[1] Hamamatsu Univ Sch Med, Dept Orthoped Surg, Hamamatsu, Shizuoka 4313192, Japan

[2] Mitsubishi Kagaku BCL, Tokyo, Japan

来源：

CLINICAL RHEUMATOLOGY | 2002年 / 21卷 / 06期

关键词：

osteoarthritis; rheumatoid arthritis; total hip replacement; total knee replacement;

D O I：

10.1007/s100670200120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Matrix metalloproteinase (MMP) and tissue inhibitor of metal loproteinase (TIMP) have been reported to be associated with arthritis. Total joint replacement results in total resection of cartilage and synovium at the joint. We investigated longitudinal changes in plasma NIMP and TIMP after total joint replacement. Eight patients with osteoarthritis (OA) and 15 patients with rheumatoid arthritis (RA) had total knee or total hip replacements. Plasma was collected from all patients before surgery and at I week and 6 weeks after surgery. In RA patients the plasma MMP-3 and the MMP-3/TIMP-1 ratio decreased after total joint replacement, whereas CRP and ESR did not change. Therefore, CRP and ESR reflect systemic inflammation; however, plasma MMP-3 and the MMP-3/TIMP-1 ratio may reflect inflammation and/or degeneration of the affected joint.

引用

页码：488 / 492

页数：5

共 33 条

[1] C-reactive protein values and erythrocyte sedimentation rates after total hip and total knee arthroplasty [J].