Urease inhibitors from Hypericum oblongifolium WALL.

被引：84

作者：

Arfan, Mohammad ^{[2
]}

Ali, Mumtaz ^{[2
]}

Ahmad, Habib ^{[3
]}

Anis, Itrat ^{[4
]}

Khan, Ajmal ^{[1
]}

Choudhary, M. Iqbal ^{[1
]}

Shah, Muhammad Raza ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[2] Univ Peshawar, Inst Chem Sci, Peshawar, Pakistan

[3] Hazara Univ, Dept Bot, Dudial, Mansehra, Pakistan

[4] Univ Karachi, Dept Chem, Karachi 75270, Pakistan

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2010年 / 25卷 / 02期

关键词：

Hypericum oblongifolium; guttiferae; urease inhibitors;

D O I：

10.3109/14756360903179385

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The bioassay-guided fractionation of H. oblongifolium has led to the isolation of potent urease inhibitors 1-3. The structures were elucidated by NMR and mass spectroscopic techniques. Compound 2 showed a potent enzyme inhibition activity (IC50 20.96 +/- 0.93), which is comparatively higher than that for the standard thiourea (IC50 21.01 +/- 0.51 mu M). Compounds 1 and 3 also showed a significant activity, with IC50 37.95 +/- 1.93 and 138.43 +/- 1.23 mu M, respectively. The sub crude fractions (F1, F2, F3, and F4) were tested in vitro for their urease inhibition activity. Fractions F2 and F4 showed significant activity with IC50 140.37 +/- 1.93 and 167.43 +/- 3.03 mu M, respectively.

引用

页码：296 / 299

页数：4

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