Mighty piwis defend the germline against genome intruders

被引：205

作者：

O'Donnell, Kathryn A.

Boekel, Jef D.

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, High Throughput Biol Ctr, Baltimore, MD 21205 USA

来源：

CELL | 2007年 / 129卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.cell.2007.03.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi) effector proteins that are associated with a recently discovered group of small RNAs (piRNAs). Recent studies in Drosophila and zebrafish directly implicate Piwi proteins in piRNA biogenesis to maintain transposon silencing in the germline genome (Brennecke et al., 2007; Gunawardane et al., 2007; Houwing et al., 2007). This function may be conserved in mice as loss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with increased transposon activity (Carmell et al., 2007).

引用

页码：37 / 44

页数：8

共 40 条

[1] Meiotic transvection in fungi [J].

Aramayo, R ;

Metzenberg, RL .

CELL, 1996, 86 (01) :103-113

[2] The small RNA profile during Drosophila melanogaster development [J].

Aravin, AA ;

Lagos-Quintana, M ;

Yalcin, A ;

Zavolan, M ;

Marks, D ;

Snyder, B ;

Gaasterland, T ;

Meyer, J ;

Tuschl, T .

DEVELOPMENTAL CELL, 2003, 5 (02) :337-350

[3] A novel class of small RNAs bind to MILI protein in mouse testes [J].

Aravin, Alexei ;

Gaidatzis, Dimos ;

Pfeffer, Sebastien ;

Lagos-Quintana, Mariana ;

Landgraf, Pablo ;

Iovino, Nicola ;

Morris, Patricia ;

Brownstein, Michael J. ;

Kuramochi-Miyagawa, Satomi ;

Nakano, Toru ;

Chien, Minchen ;

Russo, James J. ;

Ju, Jingyue ;

Sheridan, Robert ;

Sander, Chris ;

Zavolan, Mihaela ;

Tuschl, Thomas .

NATURE, 2006, 442 (7099) :203-207

[4] Lessons from the genome sequence of Neurospora crassa:: Tracing the path from genomic blueprint to multicellular organism [J].

Borkovich, KA ;

Alex, LA ;

Yarden, O ;

Freitag, M ;

Turner, GE ;

Read, ND ;

Seiler, S ;

Bell-Pedersen, D ;

Paietta, J ;

Plesofsky, N ;

Plamann, M ;

Goodrich-Tanrikulu, M ;

Schulte, U ;

Mannhaupt, G ;

Nargang, FE ;

Radford, A ;

Selitrennikoff, C ;

Galagan, JE ;

Dunlap, JC ;

Loros, JJ ;

Catcheside, D ;

Inoue, H ;

Aramayo, R ;

Polymenis, M ;

Selker, EU ;

Sachs, MS ;

Marzluf, GA ;

Paulsen, I ;

Davis, R ;

Ebbole, DJ ;

Zelter, A ;

Kalkman, ER ;

O'Rourke, R ;

Bowring, F ;

Yeadon, J ;

Ishii, C ;

Suzuki, K ;

Sakai, W ;

Pratt, R .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2004, 68 (01) :1-+

[5] Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L [J].

Bourc'his, D ;

Bestor, TH .

NATURE, 2004, 431 (7004) :96-99

[6]

Brennecke J, 2007, CELL, V128, P1089, DOI 10.1016/j.cell.2007.01.043

[7] THE RELATIONSHIP BETWEEN THE FLAMENCO GENE AND GYPSY IN DROSOPHILA - HOW TO TAME A RETROVIRUS [J].

BUCHETON, A .

TRENDS IN GENETICS, 1995, 11 (09) :349-353

[8] The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis [J].

Carmell, MA ;

Xuan, ZY ;

Zhang, MQ ;

Hannon, GJ .

GENES & DEVELOPMENT, 2002, 16 (21) :2733-2742

[9]

CARMELL MA, 2007, DEV CELL

[10] On the origin and functions of RNA-mediated silencing: from protists to man [J].

Cerutti, Heriberto ;

Casas-Mollano, J. Armando .

CURRENT GENETICS, 2006, 50 (02) :81-99

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