A methylation rendezvous: Reader meets writers

被引:38
作者
Brenner, Carmen [1 ]
Fuks, Francois [1 ]
机构
[1] Free Univ Brussels, Fac Med, Lab Canc Epigenet, B-1070 Brussels, Belgium
关键词
D O I
10.1016/j.devcel.2007.05.011
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
It is well established that two marks of silent chromatin, DNA methylation and histone H3 methylation at lysine 9, engage in an epigenetic conversation. In a recent issue of Genes & Development, Smallwood et al. (2007) report that the mammalian HP1 adaptor "translates" methylation information from histone to DNA, helping to cement epigenetic expression states.
引用
收藏
页码:843 / 844
页数:2
相关论文
共 10 条
[1]   Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication [J].
Esteve, Pierre-Olivier ;
Chin, Hang Gyeong ;
Smallwood, Andrea ;
Feehery, George R. ;
Gangisetty, Omkaram ;
Karpf, Adam R. ;
Carey, Michael F. ;
Pradhan, Sriharsa .
GENES & DEVELOPMENT, 2006, 20 (22) :3089-3103
[2]   HP1 is essential for DNA methylation in Neurospora [J].
Freitag, M ;
Hickey, PC ;
Khlafallah, TK ;
Read, ND ;
Selker, EU .
MOLECULAR CELL, 2004, 13 (03) :427-434
[3]   DNA methylation and histone modifications: teaming up to silence genes [J].
Fuks, F .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (05) :490-495
[4]   The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase [J].
Fuks, F ;
Hurd, PJ ;
Deplus, R ;
Kouzarides, T .
NUCLEIC ACIDS RESEARCH, 2003, 31 (09) :2305-2312
[5]   De novo CpG island methylation in human cancer cells [J].
Jair, KW ;
Bachman, KE ;
Suzuki, H ;
Ting, AH ;
Rhee, I ;
Yen, RWC ;
Baylin, SB ;
Schuebel, KE .
CANCER RESEARCH, 2006, 66 (02) :682-692
[6]   Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin [J].
Lehnertz, B ;
Ueda, Y ;
Derijck, AAHA ;
Braunschweig, U ;
Perez-Burgos, L ;
Kubicek, S ;
Chen, TP ;
Li, E ;
Jenuwein, T ;
Peters, AHFM .
CURRENT BIOLOGY, 2003, 13 (14) :1192-1200
[7]   Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3 [J].
Lindroth, AM ;
Shultis, D ;
Jasencakova, Z ;
Fuchs, J ;
Johnson, L ;
Schubert, D ;
Patnaik, D ;
Pradhan, S ;
Goodrich, J ;
Schubert, I ;
Jenuwein, T ;
Khorasanizadeh, S ;
Jacobsen, SE .
EMBO JOURNAL, 2004, 23 (21) :4146-4155
[8]   Allosteric activator domain of maintenance human DNA (cytosine-5) methyltransferase and its role in methylation spreading [J].
Pradhan, S ;
Estève, PO .
BIOCHEMISTRY, 2003, 42 (18) :5321-5332
[9]   Functional cooperation between HP1 and DNMT1 mediates gene silencing [J].
Smallwood, Andrea ;
Esteve, Pierre-Olivier ;
Pradhan, Sriharsa ;
Carey, Michael .
GENES & DEVELOPMENT, 2007, 21 (10) :1169-1178
[10]   Profile of histone lysine methylation across transcribed mammalian chromatin [J].
Vakoc, Christopher R. ;
Sachdeva, Mira M. ;
Wang, Hongxin ;
Blobel, Gerd A. .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (24) :9185-9195