TGF-α and olfactory marker protein enhance mitosis in rat olfactory epithelium in vivo

被引：19

作者：

Farbman, AI ^{[1
]}

Ezeh, PI ^{[1
]}

机构：

[1] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

来源：

NEUROREPORT | 2000年 / 11卷 / 16期

关键词：

mitosis; neurogenesis; olfactory epithelium; olfactory marker protein; TGF-alpha; transforming growth factor-alpha;

D O I：

10.1097/00001756-200011090-00051

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies demonstrated that both transforming growth factor-alpha (TGF-alpha) and olfactory marker protein (OMP) are potent enhancers of mitosis in fetal rat olfactory epithelium grown in organotypic culture. Here we show that when either of these two peptides is administered to adult rats they elicit a significant increase in uptake of tritiated thymidine ([H-3]TdR) by olfactory epithelium. In addition OMP promotes an increase in uptake of [H-3]TdR in liver, but TGF-alpha has no effect. The data argue that both peptides regulate the rate of cell division in rat olfactory epithelium in vivo and in vitro, and suggest there may be redundancy in the regulatory apparatus modulating cell division in this tissue. NeuroReport 11:3655-3658 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3655 / 3658

页数：4

共 26 条

[1]

BEHRENS M, 2000, ACHEMS ABSTR, V22, P32

[2]

Carr VM, 1998, J NEUROBIOL, V34, P377, DOI 10.1002/(SICI)1097-4695(199803)34:4<377::AID-NEU7>3.0.CO

[3]

2-3

[4] ABLATION OF THE OLFACTORY-BULB UP-REGULATES THE RATE OF NEUROGENESIS AND INDUCES PRECOCIOUS CELL-DEATH IN OLFACTORY EPITHELIUM [J].

CARR, VM ;

FARBMAN, AI .

EXPERIMENTAL NEUROLOGY, 1992, 115 (01) :55-59

[5] A NEU ACQUAINTANCE FOR ERBB3 AND ERBB4 - A ROLE FOR RECEPTOR HETERODIMERIZATION IN GROWTH SIGNALING [J].

CARRAWAY, KL ;

CANTLEY, LC .

CELL, 1994, 78 (01) :5-8

[6]

CHALAZONITIS A, 1992, J NEUROSCI, V12, P583

[7]

Ezeh PI, 1998, J NEUROBIOL, V37, P199, DOI 10.1002/(SICI)1097-4695(19981105)37:2<199::AID-NEU1>3.0.CO

[8]

2-F

[9] Does olfactory marker protein participate in olfactory neurogenesis? [J].

Farbman, AI ;

Buchholz, JA ;

Walters, E ;

Margolis, FL .

OLFACTION AND TASTE XII: AN INTERNATIONAL SYMPOSIUM, 1998, 855 :248-251

[10]

FARBMAN AI, 1988, J NEUROSCI, V8, P3290

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