Oligodendroglioma cell lines containing t(1;19)(q10;p10)

被引：65

作者：

Kelly, John J. P.

Blough, Michael D. ^{[2
]}

Stechishin, Owen D. M.

Chan, Jennifer A. W. ^{[3
]}

Beauchamp, Desiree

Perizzolo, Marco ^{[3
]}

Demetrick, Doug J. ^{[3
]}

Steele, Lisa

Auer, Roland N. ^{[3
]}

Hader, Walter J. ^{[2
]}

Westgate, Morgan ^{[2
]}

Parney, Ian F. ^{[4
]}

Jenkins, Robert ^{[5
]}

Cairncross, J. Gregory ^{[2
]}

Weiss, Samuel ^{[1
]}

机构：

[1] Univ Calgary, Fac Med, Hotchkiss Brain Inst, Clark Smith Brain Tumor Ctr,Dept Cell Biol & Anat, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2N 4N1, Canada

[4] Mayo Clin, Dept Neurosurg, Rochester, MN USA

[5] Mayo Clin, Dept Pathol & Lab Med, Rochester, MN USA

来源：

NEURO-ONCOLOGY | 2010年 / 12卷 / 07期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

19q; 1p; brain tumor stem cell; IDH1; oligodendroglioma; translocation; CENTRAL-NERVOUS-SYSTEM; TUMOR STEM-CELLS; HUMAN GLIOBLASTOMA; 19Q; 1P; IDENTIFICATION; GLIOMAS; TEMOZOLOMIDE; DELETIONS; EGF;

D O I：

10.1093/neuonc/noq031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Investigating the biology of oligodendroglioma and its characteristic combined deletion of chromosomal arms 1p and 19q, mediated by an unbalanced translocation, t(1;19)(q10;p10), has been hampered by the lack of cell lines that harbor these traits. We grew cells from 2 anaplastic oligodendrogliomas in serum-free conditions. Serial propagation and expansion led to the establishment of permanent cell lines that maintained the genetic signature of the parent oligodendrogliomas and displayed features of brain tumor stem cells in vitro. One line was established from a treatment-naive tumor and the other from a temozolomide resistant recurrent tumor. These lines may be important tools for understanding the biology of oligodendrogliomas and the function of their defining genetic traits.

引用

页码：745 / 755

页数：11

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