In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii

被引：72

作者：

Barbosa, JP

Pereira, RC

Abrantes, JL

dos Santos, CCC

Rebello, MA

Frugulhetti, ICDP

Teixeira, VL

机构：

[1] Univ Fed Fluminense, Inst Biol, Dept Biol Marinha, BR-24001970 Niteroi, RJ, Brazil

[2] Univ Fed Fluminense, Inst Quim, Programa Posgrad Quim Organ, BR-24001970 Niteroi, RJ, Brazil

[3] Univ Fed Fluminense, Inst Biol, Dept Biol Celular & Mol, Niteroi, RJ, Brazil

[4] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo Goes, Rio De Janeiro, Brazil

来源：

PLANTA MEDICA | 2004年 / 70卷 / 09期

关键词：

Dictyota pfaffii; Dictyotales; dolabellanes; marine diterpenoids; antiviral activity; HSV-1; HIV-1;

D O I：

10.1055/s-2004-827235

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-dihydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude extract of D. pfaffli. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.

引用

页码：856 / 860

页数：5

共 20 条

[1] A dolabellane diterpene from the Brazilian brown alga Dictyota pfaffii [J].