Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with oral squamous cell carcinoma

被引：142

作者：

Watanabe, Yoshiko

Katou, Fuminori ^{[1
]}

Ohtani, Haruo ^{[2
]}

Nakayama, Takashi ^{[3
]}

Yoshie, Osamu ^{[3
]}

Hashimoto, Kenji

机构：

[1] Hamamatsu Univ Sch Med, Dept Oral & Maxillofacial Surg, Higashi Ku, Hamamatsu, Shizuoka 4313125, Japan

[2] Mito Med Ctr, Dept Pathol, Ibaraki, Japan

[3] Kinki Univ, Dept Microbiol, Osaka, Japan

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2010年 / 109卷 / 05期

关键词：

PROGNOSTIC-FACTOR; OVARIAN-CANCER; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; CERVICAL-CANCER; POOR SURVIVAL; EFFECTOR; RECRUITMENT; IMMUNOSURVEILLANCE; SUPPRESSION;

D O I：

10.1016/j.tripleo.2009.12.015

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Objective. The objective of this study was to clarify the prognostic significance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC); the present study analyzed various TIL-related parameters. Study design. Immunohistochemistry was performed in 87 patients with OSCC for the following TIL-related parameters: nest-CD8(+) T cells, stromal CD8(+) T cells, CD4(+) T cells, total regulatory T cells (Tregs), CCR4(+) Tregs, ratio of nest CD8(+) T cells/CCR4(+) Tregs, and ratio of stromal CD8(+) T cells/CCR4(+) Tregs. Results. In univariate analyses, the following parameters were associated with decreased survival: few nest-and stromal CD8(+) T cells and more stromal CCR4(+) Tregs, but not total Tregs. Low ratios of nest and stromal CD8(+) T cell/CCR4(+) Treg were associated with worse survival. In multivariate analysis, the stromal CD8(+) T cell/CCR4(+) Treg ratio was an independent prognostic factor. Conclusion. Host immune responses in the stroma of OSCC affect the survival of the patients. The in situ balance between effector T cells and regulatory T cells is the most important factor predicting survival. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 744-752)

引用

页码：744 / 752

页数：9

共 36 条

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[2]

Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL [J].