Mitochondrial DNA mutations and aging

被引：42

作者：

Krishnan, Kim J. ^{[1
]}

Greaves, Laura C. ^{[1
]}

Reeve, Amy K. ^{[1
]}

Turnbull, Douglass M. ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Mitochondrial Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

BIOGERONTOLOGY: MECHANISMS AND INTERVENTIONS | 2007年 / 1100卷

基金：

英国惠康基金;

关键词：

mitochondria; aging; mtDNA mutations; reactive oxygen species;

D O I：

10.1196/annals.1395.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria have been hypothesized to play a role in both aging and neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease. Many studies have shown the accumulation of mitochondrial DNA (mtDNA) mutations in post-mitotic tissues and more recent data have shown this also to be a feature of aging mitotic tissues. Much of this data has been correlative, until recently with the development of polymerase gamma deficient mice which accumulate high levels of mtDNA mutations and show a premature aging phenotype, that a more causative role has been proposed. This article focuses on recent developments in aging research into the role that mtDNA mutations play in the aging process.

引用

页码：227 / 240

页数：14

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