Nodal signaling: developmental roles and regulation

被引:410
作者
Shen, Michael M. [1 ]
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol, Piscataway, NJ 08854 USA
[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat, Piscataway, NJ 08854 USA
来源
DEVELOPMENT | 2007年 / 134卷 / 06期
关键词
D O I
10.1242/dev.000166
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Nodal-related ligands of the transforming growth factor-beta (TGF beta) superfamily play central roles in patterning the early embryo during the induction of mesoderm and endoderm and the specification of left-right asymmetry. Additional roles for this pathway in the maintenance of embryonic stem cell pluripotency and in carcinogenesis have been uncovered more recently. Consistent with its crucial developmental functions, Nodal signaling is tightly regulated by diverse mechanisms including the control of ligand processing, utilization of coreceptors, expression of soluble antagonists, as well as positive and negative-feedback activities.
引用
收藏
页码:1023 / 1034
页数:12
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