Determination of atenolol at a graphite-polyurethane composite electrode

被引：46

作者：

Cervini, Priscila ^{[1
]}

Ramos, Luiz Antonio ^{[1
]}

Gomes Cavalheiro, Eder Tadeu ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP, Brazil

来源：

TALANTA | 2007年 / 72卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

atenolol; graphite-PU composite electrode; DPV;

D O I：

10.1016/j.talanta.2006.10.017

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A bare graphite-polyurethane composite was evaluated as an alternative electrode in the determination of atenolol (ATN) in pharmaceutical formulations. Using a DPV procedure, a linear analytical curve was observed in the 4-100 mu mol L-1 range with a LOD = 3.16 mu mol L-1, without need of surface renewing between successive runs, with recoveries between 95.5 and 108%. Interference of other antibypertensive drugs was observed, but not from the usual components of tablets. The results of the proposed method agreed with HPLC ones within 95% confidence level. (C) 2006 Published by Elsevier B.V.

引用

页码：206 / 209

页数：4

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