Bone mineral density in HIV-infected women taking antiretroviral therapy: a systematic review

被引：11

作者：

de Carvalho, Erico Higino ^{[1
]}

Gelenske, Thais ^{[1
]}

Bandeira, Francisco ^{[2
]}

Pessoa Militao de Albuquerque, Maria da Fatima ^{[3
]}

机构：

[1] Inst Med Integral Prof Fernando Figueira IMIP, Serv Med Interna & Endocrinol, Recife, PE, Brazil

[2] Univ Pernambuco, Fac Ciencias Med, Dept Med Interna, Recife, PE, Brazil

[3] Fundacao Oswaldo Cruz Fiocruz, Ctr Pesquisa Aggeu Magalhaes, Recife, PE, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2010年 / 54卷 / 02期

关键词：

HIV; osteoporosis; fractures; bone; bone density; highly active antiretroviral therapy; systematic review; HUMAN-IMMUNODEFICIENCY-VIRUS; BODY-COMPOSITION; TENOFOVIR DF; MASS-LOSS; OSTEOPENIA; OSTEOPOROSIS; MEN; ASSOCIATION; COMBINATION; METABOLISM;

D O I：

10.1590/S0004-27302010000200008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a high prevalence of osteoporosis in HIV-infected patients. Initially described in HIV-positive men, studies have also demonstrated a high prevalence of osteoporosis in HIV-infected women. It would appear that antiretroviral therapy (ART) plays an important role in the pathogenesis of osteoporosis in HIV-infected patients, although little is known about its importance in relation to osteoporosis and fractures in HIV-positive women. The aim of this systematic review was to evaluate the frequency of bone loss, bone mineral density (BMD) and fractures in HIV-positive women taking ART or protease inhibitors (PI). After screening 597 citations from the databases of PubMed, EMBASE and Lilacs, five studies were selected for the review. A difference was demonstrated of over 3% in the BMD at the femoral neck of HIV-positive women taking PI/ART No difference was registered in the BMD at the lumbar spine between users and non-users of PI/ART. The lack of studies has made it impossible to reach any conclusion regarding the occurrence of fractures. Am Bras Endocrinol Metab. 2010;54(2):133-42

引用

页码：133 / 142

页数：10

共 59 条

[1] BMD is reduced in HIV-infected men irrespective of treatment [J].