Mesenchymal stem cells and immunomodulation: current status and future prospects

被引：925

作者：

Gao, F. ^{[1
]}

Chiu, S. M. ^{[2
]}

Motan, D. A. L. ^{[1
]}

Zhang, Z. ^{[1
]}

Chen, L. ^{[1
]}

Ji, H-L ^{[3
]}

Tse, H-F ^{[2
]}

Fu, Q-L ^{[4
]}

Lian, Q. ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Ophthalmol, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Hong Kong, Hong Kong, Peoples R China

[3] Univ Texas Hlth Sci Ctr Tyler, Dept Cellular & Mol Biol, Tyler, TX 75708 USA

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Otorhinolaryngol Hosp, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China

来源：

CELL DEATH & DISEASE | 2016年 / 7卷

基金：

中国国家自然科学基金;

关键词：

VERSUS-HOST-DISEASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ALLERGIC AIRWAY INFLAMMATION; MARROW STROMAL CELLS; HUMAN BONE-MARROW; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; STEROID-REFRACTORY ACUTE; GROWTH-FACTOR-BETA; ADIPOSE-TISSUE; MULTIPLE-SCLEROSIS;

D O I：

10.1038/cddis.2015.327

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell-derived MSCs as an approach to immunomodulation therapy.

引用

页码：e2062 / e2062

页数：11

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