Mesenchymal stem cells: Biological characteristics and potential clinical applications

被引:148
作者
Kassem, M [1 ]
机构
[1] Odense Univ Hosp, Dept Endocrinol & Metab, DK-5000 Odense C, Denmark
关键词
D O I
10.1089/clo.2004.6.369
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Mesenchymal stem cells (MSC) are clonogenic, non-hematpoietic stem cells present in the bone marrow and are able to differentiate into multiple mesoderm-type cell lineages, for example, osteoblasts, chondrocytes, endothelial-cells and also non-mesoderm-type lineages, for example, neuronal-like cells. Several methods are currently available for isolation of the MSC based on their physical and physico-chemical characteristics, for example, adherence to plastics or other extracellular matrix components. Because of the ease of their isolation and their extensive differentiation potential, MSC are among the first stem cell types to be introduced in the clinic. Several studies have demonstrated the possible use of MSC in systemic transplantation for systemic diseases, local implantation for local tissue defects, as a vehicle for genes in gene therapy protocols or to generate transplantable tissues and organs in tissue engineering protocols. Before their widespread use in therapy, methods allowing the generation of large number of cells without affecting their differentiation potential as well as technologies that overcome immunological rejection (in case allogenic transplantation) must be developed.
引用
收藏
页码:369 / 374
页数:6
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