Synthesis of novel iodo derived bicalutamide analogs

被引:21
作者
Nair, VA
Mustafa, SM
Mohler, ML
Fisher, SJ
Dalton, JT
Miller, DD
机构
[1] Univ Tennessee, Ctr Hlth Sci, Dept Pharmaceut Sci, Memphis, TN 38163 USA
[2] Ohio State Univ, Coll Pharm, Div Pharmaceut & Pharmaceut Chem, Columbus, OH 43210 USA
关键词
bicalutamide; trifluoromethyl; sulfonyl; androgen; receptor; nonsteroidal; SARM;
D O I
10.1016/j.tetlet.2004.10.130
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of optically active nonsteroidal selective androgen receptor modulators with structures analogous to bicalutamide was prepared by replacing the trifluoromethyl group with iodine and the sulfonyl linker by oxygen. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9475 / 9477
页数:3
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