Genetic determination of acute phase reactant levels: The strong heart study

被引:34
作者
Best, LG
North, KE
Tracy, RP
Lee, ET
Howard, BV
Palmieri, V
MacCluer, JW
机构
[1] Missouri Breaks Ind Res Inc, Timber Lake, SD USA
[2] Univ N Carolina, Chapel Hill, NC USA
[3] Univ Vermont, Lab Clin Biochem Res, Burlington, VT USA
[4] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA
[5] Medstar Res Inst, Washington, DC USA
[6] Cornell Univ, Weill Med Coll, New York, NY USA
[7] SW Fdn Biomed Res, San Antonio, TX 78284 USA
关键词
inflammation; epidemiology; risk factors; cardiovascular diseases; genetics; fibrinogen; c-reactive protein; plasminogen activator inhibitor-1;
D O I
10.1159/000083032
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Objective: C-reactive protein (CRP), fibrinogen and plasminogen activating inhibitor-1 (PAI-1) are acute phase reactants (APRs); and high levels are indicative of physiologic inflammatory responses. Basal (non-stimulated) APR levels have also been shown to predict atherosclerotic complications in a number of populations. We sought to determine the relative contributions of genetic and environmental factors influencing basal serum levels of APRs. Methods: This study used univariate quantitative genetic analyses to partition the phenotypic variance of these APRs into their additive genetic and environmental components using maximum likelihood variance decomposition methods. Bivariate analyses were done to detect genetic correlation between APRs. The computer program SOLAR was used to perform these analyses. Results: The Strong Heart Study (SHS) includes information on approximately 1,294 American Indian relative pairs. The proportion of variance due to environmental and acquired covariates affecting these APRs was modest, ranging from 16-20%. The proportion of variance due to genetic factors (heritability) ranged from 24-46%. In addition, there were significant genetic correlations between CRP/fibrinogen (U = 0.41 +/- 0.12) and CRP/PAI-1 (U = 0.46 +/- 0.19); but not between fibrinogen/PAI-1. Conclusion: In the SHS cohort, the levels of APRs are determined to a substantial degree by genetic influences, and CRP shares common genetic determinants with fibrinogen and PAI-1. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:112 / 116
页数:5
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