RNA III inhibiting peptide inhibits in vivo biofilm formation by drug-resistant Staphylococcus aureus

被引：92

作者：

Giacometti, A

Cirioni, O

Gov, Y

Ghiselli, R

Del Prete, MS

Mocchegiani, F

Saba, V

Orlando, F

Scalise, G

Balaban, N

Dell'Acqua, G

机构：

[1] Labs Biol Arval SA, CH-1964 Conthey, Switzerland

[2] Univ Ancona, Inst Infect Dis & Publ Hlth, I-60128 Ancona, Italy

[3] Univ Ancona, Ist Nazl Riposo & Cura Anziani, Dept Gen Surg, I-60128 Ancona, Italy

[4] Ist Ricovero & Cura Carattere Sci, Ist Nazl Riposo & Cura Anziani, Ctr Biotechnol, Res Dept, I-60128 Ancona, Italy

[5] Tel Aviv Univ, Sackler Sch Med, Dept Human Microbiol, IL-69978 Tel Aviv, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 06期

关键词：

D O I：

10.1128/AAC.47.6.1979-1983.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.

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页码：1979 / 1983

页数：5

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