Scandium(III) triflate as an efficient and reusable catalyst for synthesis of 1,5-benzodiazepine derivatives

被引：110

作者：

De, SK ^{[1
]}

Gibbs, RA ^{[1
]}

机构：

[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, Purdue Canc Ctr, W Lafayette, IN 47906 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 11期

关键词：

D O I：

10.1016/j.tetlet.2005.01.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,3-Dihydro-1H-1,5-benzodiazepines have been synthesized in solvent-free conditions in excellent yield from o-phenylenediamines and ketones in the presence of a catalytic amount of Sc(OTf)(3). This method is a very easy, rapid, and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1811 / 1813

页数：3

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