Effect of cisplatin on the clock genes expression in the liver, heart and kidney

被引：15

作者：

Cao, Bei-Bei ^{[1
]}

Li, Dengfeng ^{[1
]}

Xing, Xiaoliang ^{[1
]}

Zhao, Yaguang ^{[1
]}

Wu, Kunyang ^{[1
]}

Jiang, Fang ^{[1
]}

Yin, Wei ^{[1
]}

Li, Jia-Da ^{[1
]}

机构：

[1] Cent S Univ, Sch Life Sci, Ctr Med Genet, 110 Xiangya St, Changsha 410078, Hunan, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 501卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Cisplatin; Tissue function; Circadian rhythm; CIRCADIAN CLOCK; INDUCED NEPHROTOXICITY; TRANSCRIPTION; PROTECTION; ACTIVATION; TOXICITY; CELLS;

D O I：

10.1016/j.bbrc.2018.05.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cisplatin is a platinum-based chemotherapy drug that is widely used to treat various types of malignancies. Although the involvement of circadian clock in cisplatin metabolism and excretion has been reported, the effect of cisplatin on circadian rhythm remains unclear. In the present study, we investigated the effects of cisplatin on clock genes expression in mouse peripheral tissues. Cisplatin induced severe nephrotoxicity, as revealed by the significant increase of blood urea nitrogen and serum creatinine levels. Moreover, cisplatin circadian time-dependently induced p21 expression in the liver, heart and kidney, with the highest increase during the dark phase. In addition, cisplatin altered the clock genes expression in the liver, heart and kidney in a tissue- and gene-specific manner. Interesting, the expression of D site of the albumin promoter binding protein (Dbp), a gene involved in detoxification and drug metabolism, was consistently suppressed in the liver, heart and kidney after cisplatin treatment, implying a role of DBP in the toxicity of cisplatin. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：593 / 597

页数：5

共 23 条

[1]

Metformin affects the circadian clock and metabolic rhythms in a tissue-specific manner [J].